Biomedical Engineer Resume
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Resume:
MEGHANA V HONNATTI
, Judicial Drive, Apt # , San Diego, CA
Cell:
CAREER SUMMARY
As a Biomedical Engineer, possess over four years of research and development experience in medical devices, technology development and product development, specifically, in MEMS, micro- and nanotechnology, microfluidics and biosensors.
TECHNICAL SKILLS
* Microfabrication:
- Processing: Class -, cleanroom; Process plan; Mask layout, Photomask fabrication; Photolithography; Physical Vapor Deposition (sputtering, thermal evaporation of metal thin films); Electroplating; Wet/dry etching (Reactive Ion Etch, microwave and RF plasma etching); Wafer cleaning; Rapid prototyping; Surface modification (plasma treatment and PEG triblock copolymer)
- Materials: Silicon, glass, SU-, gold, copper, poly(dimethylsiloxane) (PDMS)
- Testing and Characterization: Scanning Electron Microscope, MEMS Motion Analyzer, Nanospec thin film measurement system, Surface profilometer, Contact angle goniometer, Syringe pump
* Biomedical Engineering:
- Bioinstrumentation: Micro/nanomanipulation; Micro/nanoinjection; Electrophysiology (patch clamping, carbon fiber amperometry); Electrochemistry; Optical microscopy (confocal, fluorescence, DIC); Micropipette puller
- Biology: Cytotoxicity assays, Fluorescence labeling (FM, Fura, Mitotracker, Lysotracker, Texas Red, PI); Antibody labeling (biotin/streptavidin complex); Cell culture (Normal Rat Kidney, INS-, Bovine Adrenal Chromaffin cells); Cytometry
* Electrical Engineering:
Signal, image and sound processing; Statistical data analysis; Digital & analog circuit design
* Computer Skills:
AutoCAD, Freehand, SolidWorks, LASI, PULSE, Igor Pro, MATLAB, C, C++, Visual Basic, EndNote, Microsoft Office (Word, Excel, PowerPoint, Project)
WORK EXPERIENCE
Zyvex Corporation, Richardson, TX
Nov – May
Biomedical Engineer
* Microfabrication for Neuromodulation Applications
- Designed and microfabricated SU-, SU-/gold and -dimensional polymeric MEMS devices for in vitro and in vivo neural engineering applications.
- Performed process design, implementation and troubleshooting of MEMS processes to increase yield and improve performance.
- Confirmed in vitro biocompatibility of MEMS multi-electrode arrays and carbon nanotube dispersions by conducting growth curve experiments with NRK cells.
- Built a bench-top prototype of an orthopedic sensor for daily wireless monitoring of bone growth in patients with congenital bone deformities; tested for read distance, accuracy and repeatability.
- Coordinated routinely with a multidisciplinary team consisting of chemists, molecular biologists, engineers, neuroscientists and surgeons in industry, university and hospitals.
- Experienced in laboratory and cleanroom safety procedures; trained in handling and disposal of hazardous materials.
* Nanomanipulator Applications & Product Development
- Coordinated product transition from generation to through collaborations, customer feedback, attending trade shows and conferences and through interactions with internal teams which led to increase in sales by %.
- Spearheaded nanomanipulator applications development such as cellular nanosurgery, nanoinjection and directed cellular manipulation by leading experimentation and end-effector development.
- Developed test methodology for and performed drift measurements on nanomanipulator motors by using a MEMS motion analyzer and Michelson’s Interferometer to quantify product specifications.
- Managed and selected vendors for equipment and material; executed equipment set-up, calibration, training, SOP and super user.
- Participated in new product development through prototype building, market research and literature review.
- Generated data for and presented at conferences, quarterly reviews and grant proposals; Trained and mentored colleagues and interns.
Dalton Cardiovascular Research Center, Columbia, MO
Aug – Oct
Research Assistant
* BioMEMS Device Fabrication and Testing
- Designed and microfabricated poly(dimethylsiloxane) (PDMS) microfluidic channels; performed photolithographic patterning, replica molding and surface modifications.
- Devised a method for rapid solution exchange time around a cell and the measurement thereof.
- Engineered a method for accurate measurement of the departioning rate constants of fluorescent markers from cell membranes; the measured rate was X faster than by previous methods.
- Optimized the designs to reduce data variability (~%), testing time (>%) and analysis time (~%), and improve exchange rate (X faster).
- Developed software programs in Igor Pro for data analysis.
* Micromachined Silicon Biochip Characterization
- Performed electrical and electrochemical characterization of gold, silver, titanium nitride and diamond like carbon electrodes by amperometry and cyclic voltammetry.
- Implemented cell manipulation methods which improved single-cell recording efficiency on micromachined biochips from % to %.
- Conducted single cell patch-clamping experiments to obtain membrane capacitance measurements.
- Trained and mentored PhD and undergraduate students on microfluidic device design, processing and testing.
EDUCATION
* MS in Electrical Engineering, GPA: ./. Aug – Dec
University of Missouri – Columbia, USA
Thesis Title: Microfluidic Devices for Rapid Solution Exchange Advisor: Dr. Kevin D. Gillis
* BE in Electronics Engineering, GPA: ./. Aug – May
Pune University, India
PUBLICATIONS & PRESENTATIONS
. T. Kmecko, M. Honnatti and G. Hughes. “Three-dimensional Carbon Nanotube Hybrid Neural Interface for Efficient Charge Transport”, Nanotech , th Annual Meeting, Santa Clara, CA, May .
. K. Colinjivadi, J.B. Lee, Meghana Honnatti, R. Draper, M. Ellis, G. Skidmore, and G. Hughes, “Polymer microgrippers as end-effectors for biological sample manipulation,” ASME IMECE Conference, Chicago, IL, Nov. .
. H. Hu, M. Honnatti, K. D. Gillis, “Microfluidic device for rapid solution exchange to study kinetics of cell physiology”, American Physics Society (APS), th Annual Meeting of the APS Division of Fluid Dynamics, Tampa Bay, FL, Nov. .
. G. A Hughes, M. Honnatti, “Profile on Zyvex Corporation”, Nanomedicine, June , Vol. , No. , Pages -.
. M. Honnatti, S. Bhattacharya, S. Gangopadhyay, K. D. Gillis. “Measurement of the Kinetics of Dye Dissociation using Microfluidic Devices”, Biomedical Engineering Society (BMES), th Annual Fall Meeting, Philadelphia, PA, Oct. .
. M. Honnatti, G. Hughes, “Intracellular Nanosurgery” Application Note .
. M. Honnatti, G. Hughes, K. Colinjivadi, J. B. Lee, “Directed Cellular Manipulation using Polymer Grippers” Application Note .
. M. Honnatti, G. Hughes, R. Draper, “Enabling Subcellular Nanosurgery: An Application Overview”, Application Note .
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